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Updated: Feb 22, 2026
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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
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Epstein-Barr virus lymphoproliferative disease after solid organ transplantation
Susan E Prockop1, Anant Vatsayan1
1Pediatric BMT Service, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Cytotherapy
|October 3, 2017
Summary
Epstein-Barr virus (EBV) is a common infection that can cause cancer, especially in organ transplant recipients. Understanding EBV risks and immune responses is key to preventing EBV malignancies.
Area of Science:
- Virology
- Immunology
- Oncology
Background:
- Epstein-Barr virus (EBV) is a ubiquitous human oncovirus, infecting over 90% of individuals.
- EBV establishes latency by evading immune surveillance, controlled by T cells in immunocompetent individuals.
- Loss of immune control over EBV can lead to malignancies in both immune-competent and compromised individuals.
Purpose of the Study:
- To review factors predisposing solid organ transplant (SOT) recipients to EBV malignancy.
- To summarize predictors of response to initial EBV malignancy therapies.
- To discuss current therapies aimed at restoring EBV-specific immunity.
Main Methods:
- Literature review of EBV and SOT recipient complications.
- Analysis of factors influencing EBV oncogenesis in immunosuppressed populations.
- Synthesis of current therapeutic strategies for EBV-associated malignancies.
Main Results:
- EBV-driven lymphoid proliferations occur in up to 20% of SOT recipients.
- Specific immunologic factors increase EBV malignancy risk in SOT recipients.
- Predictors for therapy response in EBV malignancies are being identified.
Conclusions:
- Understanding EBV immune surveillance is crucial for identifying high-risk SOT patients.
- Targeting EBV-specific immunity restoration is a key therapeutic goal.
- Further research can enable prophylactic trials for EBV malignancies in at-risk populations.
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