Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epithelial cell-based multi-omics integration identifies SPINK5 and SRI as novel diagnostic biomarkers for ulcerative colitis.

Frontiers in pharmacology·2026
Same author

Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition.

Redox biology·2026
Same author

STK39 promotes the evolution cascade of hepatocellular carcinoma by facilitating PKR/NF-κB-mediated macrophage inflammatory response.

Oncogene·2026
Same author

Wavelet spectral-aware Kolmogorov-Arnold Network for organ and tumor segmentation.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society·2026
Same author

Immune-Related Pathological Features and Predictive Score in Intrahepatic Cholangiocarcinoma Treated With Combined Conversion Immunotherapy.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same author

CUL7-mediated KEAP1 ubiquitination promotes the progression of colon cancer via NRF2 signaling.

Cell death & disease·2026

Related Experiment Video

Updated: Feb 22, 2026

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.9K

FOXO1: Another avenue for treating digestive malignancy?

Feiyu Shi1, Tian Li2, Zhi Liu3

  • 1Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China.

Seminars in Cancer Biology
|October 3, 2017
PubMed
Summary
This summary is machine-generated.

Digestive cancers cause millions of deaths globally. This review explores how the Forkhead Box O1 (FOXO1) protein may fight these tumors, suggesting it as a potential therapeutic target.

Keywords:
AktDigestive malignancyForkhead box O1Hepatocellular carcinomamicroRNA

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.0K
Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

4.2K

Related Experiment Videos

Last Updated: Feb 22, 2026

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.9K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.0K
Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

4.2K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Digestive malignancies represent a significant global health burden, causing millions of deaths annually.
  • These cancers have surpassed lung and prostate cancer in mortality rates in recent years.
  • The transcription factor Forkhead Box O1 (FOXO1) plays a crucial role in regulating cellular functions relevant to cancer development.

Purpose of the Study:

  • To review recent research on the antineoplastic role of FOXO1 in digestive malignancies.
  • To highlight FOXO1's potential as a therapeutic target for digestive cancers.
  • To guide future research directions in this field.

Main Methods:

  • Literature review of recent studies.
  • Analysis of research investigating FOXO1's function in tumor initiation, progression, and metastasis.
  • Synthesis of findings related to FOXO1's impact on digestive malignancy.

Main Results:

  • FOXO1 is implicated in regulating key cellular processes involved in cancer.
  • Emerging evidence suggests an antineoplastic role for FOXO1 in digestive cancers.
  • FOXO1's functions are critical during tumor initiation, progression, and metastasis.

Conclusions:

  • FOXO1 exhibits significant potential as a therapeutic target for digestive malignancies.
  • Further research is warranted to fully elucidate FOXO1's mechanisms and therapeutic applications.
  • Targeting FOXO1 could offer a novel strategy for combating digestive cancers.