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Updated: Feb 22, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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MENIN loss as a tissue-specific driver of tumorigenesis

Janet W Y Li1, Xianxin Hua2, Diane Reidy-Lagunes3

  • 1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Molecular and Cellular Endocrinology
|October 3, 2017
PubMed

Insights

The MEN1 gene

Area of Science:

  • Oncogenesis
  • Tumor Suppression
  • Molecular Biology

Background:

  • The MEN1 gene encodes the tumor suppressor protein MENIN, involved in diverse cellular functions.
  • Mutations in MEN1 are implicated in hereditary and sporadic neuroendocrine tumors.
  • Understanding MENIN's role is crucial for cancer research.

Purpose of the Study:

  • To review the development and utility of in vivo models for studying Men1 mutations.
  • To summarize the known cellular activities of the MENIN protein.
  • To explore potential therapeutic vulnerabilities in tumors with MENIN loss.

Main Methods:

  • Literature review focusing on Men1 in vivo models.
  • Analysis of published data on MENIN's cellular functions.
  • Investigation of strategies for targeting MENIN-deficient tumors.

Main Results:

  • In vivo models are instrumental in dissecting Men1's context-specific roles.
  • MENIN participates in key cellular processes including DNA repair and cell cycle regulation.
  • Identifying vulnerabilities in MENIN-deficient tumors is an active area of research.

Conclusions:

  • Mutational Men1 in vivo models provide valuable insights into tumor development.
  • MENIN's multifaceted cellular activities underscore its tumor suppressor function.
  • Targeting vulnerabilities in MENIN-loss tumors offers potential therapeutic avenues.
Keywords:
MEN1MENINMultiple endocrine neoplasia type 1Pancreatic neuroendocrine tumorTumor suppressor gene

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