Brain-behavior relationships in externalizing: P3 amplitude reduction reflects deficient inhibitory control
Grace M Brennan1, Arielle R Baskin-Sommers1
1Department of Psychology, Yale University, United States.
Behavioural Brain Research
|October 3, 2017
Summary
P3 amplitude reduction (P3AR), a potential biomarker for externalizing behaviors, is linked to impaired inhibitory control. This study connects P3AR to executive function deficits, improving risk prediction for psychopathology.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Endophenotypes for psychopathology risk lack specificity.
- Externalizing behaviors are heritable and linked to P3 amplitude reduction (P3AR).
- P3AR's connection to executive function deficits, like inhibitory control, remains unclear.
Purpose of the Study:
- To investigate the link between externalizing behaviors, P3AR, and inhibitory control.
- To determine if P3AR reflects deficits in inhibitory control.
- To examine the predictive utility of P3AR and inhibitory control for real-world disinhibited behavior.
Main Methods:
- Utilized a modified oddball task with at-risk adolescents and young adults (N=74).
- Assessed externalizing behaviors, P3AR, and inhibitory control.
- Correlated psychobiological measures with real-world behavioral indicators.
Main Results:
- Externalizing behaviors were associated with P3AR.
- P3AR was linked to deficient inhibitory control.
- Both P3AR and inhibitory control uniquely and interactively predicted real-world disinhibited behavior.
Conclusions:
- P3AR directly reflects inhibitory control deficits, linking this endophenotype to executive function.
- Findings support P3AR as a valid endophenotype for externalizing psychopathology.
- Integrating psychobiological and behavioral measures enhances risk assessment for externalizing behaviors.
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