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The Impact of Autophagy on Cardiovascular Senescence and Diseases

Yuichi Sasaki1, Yoshiyuki Ikeda1, Masaaki Iwabayashi1

  • 1Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University.

International Heart Journal
|October 3, 2017
PubMed

Insights

Autophagy, a cellular cleanup process, is closely linked to cardiovascular aging. While it can protect against cardiovascular disease, excessive autophagy may harm heart and artery health.

Area of Science:

  • Cardiovascular Science
  • Cellular Biology
  • Gerontology

Background:

  • Cardiovascular disease risk rises with age, leading to significant morbidity and mortality in the elderly.
  • Cardiovascular aging involves conditions like heart failure, ischemia-reperfusion injury, cardiomyopathy, hypertension, arterial stiffness, and atherosclerosis.
  • Cellular aging leads to the accumulation of damaged organelles and proteins, necessitating cellular maintenance systems.

Purpose of the Study:

  • To summarize the current understanding of the relationship between autophagy and cardiovascular senescence.
  • To explore the dual role of autophagy in cardiovascular aging and disease.

Main Methods:

  • Literature review and synthesis of existing research on autophagy and cardiovascular aging.
  • Analysis of studies investigating the impact of autophagy on age-related cardiovascular conditions.

Main Results:

  • Autophagy is crucial for maintaining cardiovascular homeostasis by clearing cellular debris.
  • Evidence suggests autophagy plays a significant role in age-related cardiovascular diseases.
  • Dysregulation or overexpression of autophagy can have detrimental effects on the cardiovascular system.

Conclusions:

  • Autophagy is a key player in cardiovascular senescence, influencing the development and progression of cardiovascular diseases.
  • Modulating autophagy presents a potential therapeutic strategy for cardiovascular aging, but requires careful consideration of its dual effects.

Keywords:
AgingAtherosclerosisCardiovascular diseaseHeart failure

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