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Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Updated: Feb 22, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Epstein-Barr virus-positive diffuse large B-cell lymphoma.

Stacey L Murthy¹, Michael A Hitchcock¹, Tiana R Endicott-Yazdani¹

¹Departments of Pathology (Murthy, Hitchcock, Krause) and Internal Medicine (Endicott-Yazdani, Watson), Baylor University Medical Center at Dallas, Texas.

Proceedings (Baylor University. Medical Center)

|October 3, 2017

Summary

This summary is machine-generated.

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS), can affect individuals of any age. This case highlights the diagnostic criteria and rapid progression of EBV+ DLBCL, NOS.

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Area of Science:

Oncology
Virology
Pathology

Background:

The World Health Organization initially classified Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) in older adults.
Revisions in 2016 broadened the classification to "not otherwise specified" (NOS) to include younger individuals and acknowledge other specific EBV-positive large B-cell neoplasms.

Observation:

An 81-year-old woman presented with generalized weakness, confusion, weight loss, and fevers.
Physical examination revealed lymphadenopathy, liver and small intestine lesions, and a high EBV viral load.

Findings:

Autopsy confirmed Epstein-Barr virus-positive diffuse large B-cell lymphoma, not otherwise specified (EBV+ DLBCL, NOS).
Diagnosis of EBV+ DLBCL, NOS requires exclusion of other causes of immunodeficiency and specific EBV-associated large B-cell entities.

Implications:

This case underscores the importance of considering EBV+ DLBCL, NOS in a broader age range.
Accurate diagnosis and exclusion of other specific entities are critical for patient management and understanding disease spectrum.