Sinonasal and laryngeal sarcoidosis

Area of Science:

• Otorhinolaryngology
• Pulmonology
• Dermatology

Background:

• Sarcoidosis is a multisystem granulomatous disease of unknown cause.
• Sinonasal and laryngeal sarcoidosis are uncommon manifestations.
• Diagnosis and treatment of laryngeal and sinonasal sarcoidosis can be challenging due to variable presentation and poor response to corticosteroids.

Observation:

• A 55-year-old woman with a history of cutaneous sarcoidosis presented with chronic nasal congestion, dyspnea, dysphonia, and stridor.
• Symptoms suggested potential upper airway involvement.

Findings:

• Biopsy of the nasal vestibule confirmed noncaseating granulomatous inflammation, consistent with sarcoidosis.
• Histopathological findings confirmed the diagnosis in the sinonasal tract.

Implications:

• This case underscores the importance of considering sarcoidosis in patients with sinonasal and laryngeal symptoms, especially those with a history of the disease.
• Early diagnosis and appropriate management are crucial for improving patient outcomes in rare sarcoidosis presentations.
• Further research is needed to understand the pathogenesis and optimize treatment strategies for sinonasal and laryngeal sarcoidosis.