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Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats
Mengxiong Pan1,2, Peng Wang1, Chengcai Zheng1
11Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Aging and Disease
|October 3, 2017
Summary
Young blood plasma improved recovery after ischemic stroke in aged rats. Conversely, aged plasma worsened stroke outcomes in young rats, highlighting the aging systemic milieu's critical role.
Area of Science:
- Gerontology
- Neuroscience
- Vascular Biology
Background:
- Blood factors can reverse aging-related impairments in mice, rejuvenating stem cells and improving cognition.
- Systemic factors from young animals may benefit aged organisms, but their effect on stroke recovery is unknown.
Purpose of the Study:
- To investigate if a young systemic milieu improves functional recovery after ischemic stroke.
- To determine the impact of young versus aged plasma on stroke outcomes.
Main Methods:
- Aged rats underwent ischemic stroke (distal middle cerebral artery occlusion) and received young plasma.
- Young rats with ischemic stroke received aged plasma.
- Proteomic analysis identified key serum factors, including haptoglobin.
Main Results:
- Young plasma reduced infarct volume and motor impairment in aged rats post-stroke.
- Aged plasma worsened brain injury and motor deficits in young rats.
- Increased haptoglobin in aged rats correlated with impaired stroke recovery.
Conclusions:
- The aging systemic milieu significantly influences functional outcomes after ischemic stroke.
- Young plasma shows therapeutic potential for stroke recovery in aged individuals.
- Haptoglobin may be a key factor mediating the negative effects of aging on stroke outcomes.
