Related Experiment Video
Updated: Feb 22, 2026
A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
Published on: May 9, 2025
Impact of the revised WHO classification of diffuse low-grade glioma on clinical decision making: A case report
Tim A M Bouwens van der Vlis1, Ann Hoeben2, Jan C Beckervordersandforth3
1Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Background:
In the 2016 update of the World Health Organization Classification of Tumors of the central nervous system, phenotypic and genotypic parameters are integrated in diffuse low-grade glioma (LGG) tumor classification. Implementation of this combined phenotypic-genotypic characterization identifies prognostic relevant subgroups.
Case Description:
We report a case of a 67-year-old patient with an LGG that showed molecular characteristics similar to glioblastoma multiforme (GBM). After gross total tumor resection, the patient received combination therapy (radiotherapy and chemotherapy) according to high-grade glioma treatment protocol.
Conclusion:
The introduction of molecular parameters to the classification of LGG will add a level of objectivity, which will yield biological homogeneous subclasses. Consequently, this will influence patient counseling and clinical decision making regarding treatment protocols.
