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Clostridium difficile as a nosocomial pathogen.

J Silva1, C Iezzi

  • 1Department of Internal Medicine, University of California, Davis.

The Journal of Hospital Infection
|February 1, 1988
PubMed
Summary
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This study investigated Clostridium difficile-associated diarrhea (CDAD) in a hospital unit. Higher rates of CDAD occurred on the intermediate care floor, with environmental contamination found in patient rooms.

Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Microbiology

Background:

  • Clostridium difficile-associated diarrhea (CDAD) is a significant healthcare-associated infection.
  • Understanding transmission routes in hospital settings is crucial for prevention.

Purpose of the Study:

  • To investigate the incidence of CDAD on a specific intermediate nursing care floor.
  • To identify potential environmental sources of Clostridium difficile (C. difficile) in patient rooms.

Main Methods:

  • A six-month prospective study of patients admitted to a 19-bed intermediate care unit.
  • Weekly environmental sampling of patient rooms for C. difficile.
  • Comparison of CDAD incidence on the study floor versus the rest of the hospital.

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Main Results:

  • The incidence of CDAD was significantly higher on the intermediate care floor (1.73 cases/100 patients) compared to other hospital sites (0.30 cases/100 patients).
  • C. difficile was detected in environmental surfaces within patient rooms, including toilet seats and food trays.
  • A higher proportion of cases were linked to rooms with a history of CDAD.

Conclusions:

  • The intermediate nursing care floor represented a higher risk for CDAD development.
  • Environmental contamination with C. difficile likely plays a role in transmission within the hospital unit.