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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
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Respiratory mechanics to understand ARDS and guide mechanical ventilation
Tommaso Mauri1,2, Marta Lazzeri2,3, Giacomo Bellani4
1Department of Pathophysiology and Transplantation, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.
Physiological Measurement
|October 3, 2017
Summary
Respiratory mechanics assessment in acute respiratory distress syndrome (ARDS) offers personalized insights. This physiological approach guides protective mechanical ventilation, improving patient outcomes in the intensive care unit (ICU).
Area of Science:
- Critical Care Medicine
- Pulmonology
- Physiology
Background:
- Precision medicine is advancing treatment selection.
- Personalized therapy requires physiological measurements, especially in intensive care units (ICUs).
- Acute Respiratory Distress Syndrome (ARDS) management can benefit from detailed physiological assessments.
Purpose of the Study:
- To review alterations in respiratory mechanics in ARDS patients.
- To highlight respiratory mechanics as a tool for assessing ARDS severity.
- To demonstrate how respiratory mechanics can guide mechanical ventilation settings.
Main Methods:
- Systematic assessment of respiratory mechanics in ARDS patients.
- Analysis of physiological parameters like respiratory system compliance.
- Correlation of respiratory mechanics with lung injury severity and mortality.
Main Results:
- Decreased respiratory system compliance indicates more severe lung injury.
- Respiratory mechanics can guide the selection of positive end-expiratory pressure for alveolar recruitment.
- Driving airway pressure is linked to mortality, suggesting tidal volume should be based on compliance.
Conclusions:
- Respiratory mechanics provide a bedside tool for understanding ARDS severity.
- These measurements can guide protective mechanical ventilation strategies.
- This approach offers a readily available clinical resource for ICU physicians.
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