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The discrimination between human, porcine and bovine insulin with 1H NMR spectroscopy
C W Funke1, J R Mellema, P Salemink
1Scientific Development Group, Organon International, Oss, The Netherlands.
The Journal of Pharmacy and Pharmacology
|January 1, 1988
Abstract:
The 1H- and 1H-1H correlation (COSY) NMR spectra of human, porcine and bovine insulin have been recorded. The 1.1-1.5 ppm regions of these spectra show the methyl signals of the alanine and threonine residues. The number of alanines and threonines differs for the three insulins and thus allows an easy discrimination with NMR.