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The structure of phenindamine base and salts in the solute state
S K Branch1, A F Casy, R Hussain
1School of Pharmacy and Pharmacology, University of Bath, Bath, UK.
The Journal of Pharmacy and Pharmacology
|January 1, 1988
Abstract:
High-field NMR (13C and 1H) studies of phenindamine are reported which establish structures of the free base and some of its salts in the solute condition. The base exists as a mixture of two isomers which differ in double bond position (9-9a or 4a-9a) while most salts are 9-9a isomers. The clinically employed tartrate (Thephorin) is exceptional in being a 4a-9a ene. Salts of both double bond type exist in solution as mixtures of protonated epimers of variable epimeric ratio, that of the tartrate in D2O being approximately 1:1.