Related Experiment Video

Updated: Feb 21, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms.

N Venkatesan1, J F Wong1, K P Tan2,3

  • 1School of Biological Sciences, College of Science, Nanyang Technological University, Republic of Singapore.

Oncogene
|October 3, 2017
PubMed
Summary

Extranuclear EZH2 promotes cancer by methylating Talin1, enhancing cell adhesion turnover and tumorigenesis. Disrupting EZH2-VAV interaction or cytoplasmic EZH2 function halts this transformation process.

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