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Updated: Feb 21, 2026

Employing Pressurized Hot Water Extraction PHWE to Explore Natural Products Chemistry in the Undergraduate Laboratory
Published on: November 7, 2018
Harnessing the Properties of Natural Products
Asmaa Boufridi1, Ronald J Quinn1
1Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia; email: a.boufridi@griffith.edu.au , r.quinn@griffith.edu.au.
Abstract:
Natural products (NPs) have been used as traditional medicines since antiquity. With more than 1060 estimated compounds with molecular weights less than 500 Da representing chemical space, NPs occupy a very small percentage; however, they are significantly overrepresented in biologically relevant chemical space. The classical approach concentrates on identifying one or more NPs with biological activity from a source organism. There is much more to be learned from NPs than we can discover this narrow view. In this review, we discuss ways to harness the global properties of NPs.
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