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Clinical Trials Corner: September 2017

Filipe B Rodrigues1,2,3, Edward J Wild1

  • 1Huntington's Disease Centre, University College London, London, UK.

Journal of Huntington'S Disease
|October 3, 2017
PubMed

Insights

This review highlights ongoing and completed clinical trials for Huntington's disease, offering insights into key studies like LEGATO-HD and IONIS-HTTRx, as well as Amaryllis and Pride-HD.

Area of Science:

  • Neuroscience
  • Genetics
  • Clinical Research

Background:

  • Huntington's disease (HD) is a progressive neurodegenerative disorder.
  • Effective treatments are urgently needed.
  • Clinical trials are essential for developing new therapies.

Purpose of the Study:

  • To provide an overview of the current clinical trial landscape for Huntington's disease.
  • To detail specific ongoing and recently completed trials.

Main Methods:

  • Systematic review of registered and completed clinical trials.
  • In-depth discussion of selected trials, including LEGATO-HD, IONIS-HTTRx, Amaryllis, and Pride-HD.

Main Results:

  • A comprehensive list of ongoing Huntington's disease trials is presented.
  • Key findings and methodologies of LEGATO-HD, IONIS-HTTRx, Amaryllis, and Pride-HD are summarized.

Conclusions:

  • The review offers a snapshot of recent advancements in Huntington's disease clinical research.
  • It serves as a valuable resource for researchers, clinicians, and patients interested in HD therapeutic development.

Keywords:
Clinical trialsHuntington’s disease

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