Related Experiment Video
Updated: Feb 21, 2026

Three-Dimensional Reconstruction of Orbital Fractures
Published on: May 16, 2025
A Pediatric Patient With an Orbital Respiratory Epithelial Cyst
Jason E Cohn1, Arash Bahrami, Christina Monteleone
1*Department of Otolaryngology-Facial Plastic Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA †New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY ‡Department of Pathology and Laboratory Medicine §Department of Plastic Surgery, St. Christopher's Hospital for Children, Philadelphia, PA.
Insights
This study reports a rare case of an orbital respiratory epithelial cyst in a 14-month-old child. Surgical excision and histological analysis confirmed the diagnosis, highlighting a rare pediatric orbital condition.
Area of Science:
- Ophthalmology
- Pathology
- Pediatric Surgery
Background:
- Orbital respiratory epithelial cysts are rare, often congenital, and arise from ectopic respiratory tissue.
- Congenital orbital cysts are uncommon, with fewer than 15 cases of respiratory epithelial cysts documented.
Observation:
- A 14-month-old male presented with a right infraorbital cyst.
- MRI revealed a cyst displacing the eye and inferior rectus muscle.
- The cyst was hyperintense on T1 and fluid-dense on T2 MRI sequences.
Findings:
- Surgical excision via a transconjunctival approach was performed.
- Histopathology confirmed the cyst lining with ciliated columnar and mucus-containing cells.
- This represents the youngest patient reported with an orbital respiratory epithelial cyst.
Implications:
- This case expands the understanding of pediatric orbital cystic lesions.
- Early diagnosis and surgical management are crucial for favorable outcomes.
- Highlights the importance of considering rare diagnoses in pediatric ophthalmology.
Abstract:
Respiratory epithelial cysts are rare orbital cysts that can arise secondary to choristomatous rests of respiratory epithelium. Approximately 15 congenital cases have been described in the literature, making it a rare disease entity. We present a case of a 14-month-old Middle Eastern male with a right infraorbital respiratory epithelial cyst. Magnetic resonance imaging of the brain and orbits revealed a right infraorbital cyst hyperintense on T1-weighted images and followed fluid density on T2-weighted images. This cyst was noted to displace the globe superiorly and inferior rectus muscle laterally. This cyst was excised using a transconjunctival approach. Histologically, the cyst wall was lined by ciliated columnar cells with interspersed mucus-containing cells and ciliated transitional epithelium was present, establishing the diagnosis of respiratory epithelial cyst. To our knowledge, this is the youngest patient with a respiratory epithelial cyst of the orbit reported in the literature.
Related Concept Videos
Suctioning the Oropharyngeal Airway
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
Suctioning the Nasopharyngeal Airway
Equipment Required
Pulmonary Cycle: Exhalation
Cardiopulmonary Resuscitation II: ACLS Airway Management
Cystic Fibrosis: Management
Sinus disease and chronic...
Respiratory System Abnormal Finding I: Inspection and Percussion
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...

