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Modulators of 14-3-3 Protein-Protein Interactions.

Loes M Stevers1, Eline Sijbesma1, Maurizio Botta2

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS) , Eindhoven University of Technology , P.O. Box 513, 5600 MB , Eindhoven , The Netherlands.

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|October 3, 2017
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Summary

Targeting protein-protein interactions (PPIs) offers therapeutic potential. This review explores strategies for modulating 14-3-3 protein interactions using small molecules, peptides, and natural products to treat diseases.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Discovery

Background:

  • Protein-protein interactions (PPIs) are crucial for biological pathway regulation.
  • Targeting PPIs is a promising therapeutic strategy, despite historical challenges.
  • The 14-3-3 protein family acts as a hub, interacting with numerous partners in various cellular processes and diseases.

Purpose of the Study:

  • To provide an integrated overview of approaches for modulating 14-3-3 PPIs.
  • To review examples of small molecules, peptide mimetics, and natural products that inhibit or stabilize 14-3-3 complexes.

Main Methods:

  • Literature review of PPI modulation strategies.
  • Focus on the 14-3-3 protein family as a therapeutic target.
  • Analysis of small molecules, peptide mimetics, and natural products as modulators.

Main Results:

  • Successful examples of PPI modulators have emerged in the last two decades.
  • Various approaches are being explored to target 14-3-3 PPIs.
  • Inhibitors and stabilizers of specific 14-3-3 protein complexes have been identified.

Conclusions:

  • Modulating PPIs, particularly those involving 14-3-3 proteins, holds significant therapeutic promise.
  • Interdisciplinary efforts are essential for advancing PPI modulation as a drug discovery strategy.
  • Further research into 14-3-3 targeted therapies could lead to novel treatments for various diseases.