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Related Experiment Video

Updated: Feb 21, 2026

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Cerebral Cavernous Malformations: Patient-Reported Outcome Validates Conservative Management.

Vitor Chehuen Bicalho1, Anke Bergmann, Flávio Domingues

  • 1Department of Surgery, Division of Neurosurgery, Hospital Universitário Clementino Fraga Filho and Program of Post-Graduation in Surgical Sciences of the Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Cerebrovascular Diseases (Basel, Switzerland)
|October 3, 2017
PubMed
Summary

This study shows that non-operated cerebral cavernous malformations (CCM) patients can maintain quality of life and neurological function long-term. Patient-reported outcomes (PRO) using validated tools confirm clinical stability in this CCM population.

Keywords:
CavernomaCavernous angiomaCerebral cavernous malformationGradiente echoQuality of life

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Area of Science:

  • Neurology
  • Vascular Biology
  • Patient-Reported Outcomes

Background:

  • Cerebral cavernous malformations (CCM) are prevalent CNS vascular malformations affecting 0.4-0.6% of the population.
  • CCM complications include bleeding, neurological deficits, and drug-refractory epilepsy, impacting patient quality of life (QoL).
  • Patient-reported outcomes (PRO) offer a strategy to evaluate QoL in CCM patients, particularly those not undergoing surgery.

Purpose of the Study:

  • To evaluate the patient-reported outcomes (PRO) and quality of life (QoL) in a cohort of non-operated cerebral cavernous malformation (CCM) patients.
  • To assess functional metrics using the Karnofsky Performance Status (KPS) in conjunction with QoL questionnaires.
  • To determine if long-term clinical stability is achievable without surgical intervention in selected CCM patients.

Main Methods:

  • An observational, cross-sectional analysis was conducted on 49 non-operated CCM patients.
  • Quality of life was assessed using the SF-36 and EuroQol 5 dimensions (EQ-5D) questionnaires.
  • Functional status was evaluated using the Karnofsky Performance Status (KPS) scale over a mean follow-up of 7.42 years.

Main Results:

  • Patients with KPS <100 reported worse scores in pain, vitality, and general health domains of the SF-36.
  • The mental health domain of the SF-36 was worse in patients without a surgical indication.
  • Lower scores were observed in mobility and pain/discomfort dimensions of the EQ-5D compared to KPS <100.

Conclusions:

  • This study is the first to use validated tools to assess PRO in non-operated CCM patients.
  • Long-term clinical stability was demonstrated in a selected group of non-operated CCM patients.
  • Maintaining QoL and functional neurological outcomes is possible in non-operated CCM patients, suggesting PROs are valuable assessment tools.