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Identification of human herpesvirus-6 as a causal agent for exanthem subitum
K Yamanishi1, T Okuno, K Shiraki
1Department of Virology, Osaka University, Japan.
Lancet (London, England)
|May 14, 1988
Abstract:
A virus was isolated from the peripheral blood lymphocytes of patients with exanthem subitum, cultured successfully in cord blood lymphocytes, and shown to be antigenically related to human herpesvirus-6 (HHV-6). Morphological features, as studied by thin-section electronmicroscopy, resembled those of herpes group viruses. Convalescent-phase serum samples, tested against the new viral antigen and HHV-6 antigen, showed seroconversion. The results strongly suggest that the newly isolated virus is identical or closely related to HHV-6 and the causal agent for exanthem subitum.