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Antimicrobial Activity of Honey with Special Reference to Methicillin Resistant Staphylococcus aureus (MRSA) and
Guruvu Neeraja Rani1, Radhika Budumuru2, Narasinga Rao Bandaru3
1Research Scholar, Saveetha University, Chennai, Tamil Nadu, India.
Introduction:
Antimicrobial agents are essentially important in reducing the global burden of infectious diseases. With the irrational and excessive use of antibiotics in underdeveloped and developing countries, there may be chances to develop and spread resistant pathogens in the community. As a result, the effectiveness of the antibiotics is diminishing. Therefore, the need for novel alternative antimicrobial strategies has renewed interest in natural products like turmeric, honey, ginger and others exhibiting antibacterial properties. This situation has led to a re-evaluation of the therapeutic use of ancient remedies like honey as no other studies are available in the state of Andhra Pradesh with the locally available honey.
Aim:
To find out the efficacy of antibacterial activity of locally available honey against Methicillin Resistant Staphylococcusaureus (MRSA) and Methicillin Sensitive Staphylococcus aureus (MSSA) isolates.
Materials And Methods:
A prospective study on the antibacterial activity of Bharat multi floral pasteurised honey which was locally available in the state of Andhra Pradesh, further it was conducted and evaluated against the bacterial strains of Methicillin Resistant Staphylococcus aureus and Methicillin Sensitive Staphylococcus aureus. Their antibacterial sensitivity pattern was tested using Kirby-Bauer disc diffusion susceptibility testing technique of CLSI along with other commonly used antimicrobials.
Results:
Both MRSA and MSSA isolates were sensitive to honey. But MRSA were resistant to all antimicrobials tested except linezolid where as MSSA were sensitive to all except penicillin.
Conclusion:
It is definitely worthy to consider honey as a promising future antimicrobial to be tested and studied. Honey, may be elaborately used in future with some more molecular studies on its method of action as an antimicrobial agent.
Insights
Local honey demonstrated antibacterial activity against both Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Sensitive Staphylococcus aureus (MSSA). This finding highlights honey
Area of Science:
- Microbiology
- Natural Products Chemistry
- Infectious Diseases
Background:
- The rise of antibiotic resistance necessitates the exploration of alternative antimicrobial agents.
- Natural products, such as honey, are being re-evaluated for their therapeutic potential.
- Limited research exists on the antibacterial properties of honey from Andhra Pradesh, India.
Purpose of the Study:
- To assess the antibacterial efficacy of locally sourced honey against Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Sensitive Staphylococcus aureus (MSSA).
Main Methods:
- Prospective study evaluating Bharat multi floral pasteurised honey from Andhra Pradesh.
- Antibacterial activity tested against MRSA and MSSA isolates.
- Kirby-Bauer disc diffusion susceptibility testing used, comparing honey to standard antimicrobials.
Main Results:
- Both MRSA and MSSA isolates exhibited sensitivity to honey.
- MRSA strains were resistant to most tested antimicrobials, except linezolid.
- MSSA strains were sensitive to all antimicrobials except penicillin.
Conclusions:
- Honey shows promise as a future antimicrobial agent.
- Further molecular studies are warranted to elucidate honey's antimicrobial mechanism of action.
- Local honey could be a valuable addition to antimicrobial strategies.
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