Primary Merkel Cell Carcinoma on the Cheek: Three Case Reports

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
• MCC typically develops on sun-exposed skin surfaces.
• Primary MCC of the cheek is uncommon, necessitating case study analysis.

Observation:

• Three cases of primary Merkel cell carcinoma on the cheek are presented.
• Clinical presentations included nodules and swelling.
• Treatment modalities ranged from no intervention to surgical resection with reconstruction.

Findings:

• Outcomes varied significantly, with survival times of 10 months, 21 months, and no recurrence/metastasis observed.
• Aggressive nature and treatment response influence Merkel cell carcinoma prognosis.
• Histopathological and clinical features are crucial for diagnosis and management.

Implications:

• This case series highlights the variable clinical course and prognosis of primary Merkel cell carcinoma of the cheek.
• Understanding MCC's presentation and treatment response is vital for optimizing patient care.
• Further research into MCC pathogenesis and therapeutic strategies is warranted.