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Updated: Feb 21, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Evidence-based health care: A roadmap for knowledge translation
Chien-Yu Chen1, Tsai-Wei Huang2, Ken N Kuo3
1Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan, ROC; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.
Bridging the gap between research and clinical practice requires integrating evidence-based healthcare concepts. A knowledge translation roadmap, emphasizing transparency, systematic reviews, and shared decision-making, can improve patient care quality.
Area of Science:
- Health Services Research
- Clinical Practice Improvement
- Knowledge Translation
Background:
- Evidence-based healthcare (EBH) provides clinicians with effective care choices based on research.
- Current EBH concepts and tools are fragmented for many clinicians, leading to practice gaps.
- Significant discrepancies persist between research findings and daily clinical application.
Purpose of the Study:
- To propose a knowledge translation roadmap to bridge the gap between evidence and clinical practice.
- To enhance the integration of EBH concepts for improved healthcare quality.
- To identify key strategies for diminishing the evidence-practice divide.
Main Methods:
- The study outlines a conceptual roadmap for knowledge translation in healthcare.
- It emphasizes the integration of various evidence-based healthcare concepts.
- Key strategies discussed include improving research transparency and accuracy.
Main Results:
- A knowledge translation roadmap can facilitate the integration of EBH concepts.
- Improving research transparency and accuracy is crucial.
- Conducting updated systematic reviews is essential for evidence synthesis.
- Shared decision-making empowers clinicians and patients.
Conclusions:
- A structured knowledge translation approach is necessary to overcome EBH fragmentation.
- Implementing strategies like research transparency, systematic reviews, and shared decision-making can reduce the evidence-practice gap.
- This roadmap aims to enhance the quality of patient care through better evidence utilization.
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