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Updated: Feb 21, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Published on: June 7, 2016

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AGXT2: An unnegligible aminotransferase in cardiovascular and urinary systems

Xiao-Lei Hu1, Mu-Peng Li1, Pei-Yuan Song1

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.

Journal of Molecular and Cellular Cardiology
|October 4, 2017
PubMed

Insights

Alanine-glyoxylate aminotransferase 2 (AGXT2) impacts cardiovascular diseases (CVDs) and renal impairment by regulating dimethylarginine levels. AGXT2 deficiency may contribute to disease progression, highlighting its role in cardiorenal health.

Area of Science:

  • Biochemistry
  • Cardiology
  • Nephrology

Background:

  • Cardiovascular diseases (CVDs) and renal impairment exhibit complex interactions.
  • Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are implicated in CVD development and prognosis.
  • ADMA and SDMA plasma levels correlate with renal function.

Purpose of the Study:

  • To investigate the role of Alanine-glyoxylate aminotransferase 2 (AGXT2) in cardiovascular and renal diseases.
  • To explore the impact of AGXT2 on ADMA/SDMA metabolism and its potential contribution to disease progression.

Main Methods:

  • Review of existing literature on AGXT2 function and metabolism.
  • Analysis of studies linking AGXT2 to cardiovascular and renal systems.
  • Discussion of the relationship between AGXT2, ADMA/SDMA levels, and disease pathogenesis.

Main Results:

  • AGXT2 is involved in the metabolism of ADMA and SDMA.
  • AGXT2 deficiency may influence ADMA/SDMA levels, potentially affecting cardiorenal health.
  • Clinical studies show associations between AGXT2 and cardiovascular/urinary system conditions.

Conclusions:

  • AGXT2 plays a significant role in regulating dimethylarginine levels, impacting cardiorenal health.
  • Understanding AGXT2's function offers insights into the pathogenesis of CVDs and renal diseases.
  • Further research into AGXT2 may reveal novel therapeutic targets for cardiorenal conditions.

Keywords:
ADMAAGXT2Cardiovascular diseasesRenal diseasesSDMASNP

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