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Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

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Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...
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Related Experiment Video

Updated: Feb 21, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Published on: January 29, 2018

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Authors' reply

Irina Falkenberg1, Stefania Benetti1, Marie Raffin1

  • 1Irina Falkenberg, MD, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK and Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany; Stefania Benetti, PhD, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Marie Raffin, MD, Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, Paris, France; Phillipe Wuyts, MD, EDHEC Business School, Nice, France; William Pettersson-Yeo, PhD, Paola Dazzan, MBChB, MSc, MRCPsych, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Kevin D. Morgan, PhD, Department of Psychology, University of Westminster, London, UK; Robin M. Murray, MBChB, MPhil, FRCPsych, Tiago Reis Marques, PhD, Anthony S. David, FRCP, FRCPsych, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Jozef Jarosz, MD, Department of Neuroimaging, South London and Maudsley NHS Foundation Trust, London and Department of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Andrew Simmons, PhD, Steve Williams, Professor, Department of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Philip McGuire, Professor, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

The British Journal of Psychiatry : the Journal of Mental Science
|October 4, 2017
PubMed
Summary

No abstract available in PubMed .

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