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Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
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Severe pulmonary hypertension and right ventricular failure
Ajay Kumar1, Praveen Kumar Neema1
1Department of Anaesthesiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Indian Journal of Anaesthesia
|October 4, 2017
Summary
Managing severe pulmonary hypertension (PH) during surgery requires understanding its pathophysiology and novel treatments. This review covers PH management, anesthesia considerations, new drugs, and mechanical devices for right ventricular support.
Area of Science:
- Cardiology
- Anesthesiology
- Pulmonary Medicine
Background:
- Perioperative management of severe pulmonary hypertension (PH) presents significant challenges for anesthesiologists.
- Cases include incidental surgeries, congenital and valvular heart diseases, and obstetric procedures like Cesarean sections in patients with Eisenmenger syndrome.
Purpose of the Study:
- To provide a comprehensive understanding of the pathophysiology of pulmonary hypertension.
- To guide anesthesiologists in managing patients with PH, including the use of novel pharmacologic agents and mechanical devices.
Main Methods:
- This review synthesizes current knowledge on PH pathophysiology.
- It discusses anesthetic considerations for patients with PH.
- It explores novel drug therapies and mechanical support for right ventricular failure.
Main Results:
- Effective management hinges on a thorough understanding of PH pathophysiology.
- Novel drugs offer new therapeutic avenues.
- Mechanical devices can be crucial for supporting a failing right ventricle.
Conclusions:
- Anesthesiologists require updated knowledge on PH pathophysiology and emerging treatments.
- Optimizing perioperative care for PH patients involves a multidisciplinary approach.
- The review highlights the importance of novel drugs and mechanical support in improving outcomes.
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