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Rapid dry plasma thawing system: An alternative to conventional thawing baths
S Sanooja Pinki1, Ganesh Mohan1, Aboobacker Mohamed Rafi1
1Department of Immunohematology and Blood Transfusion, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
Asian Journal of Transfusion Science
|October 4, 2017
Summary
Dry thawing using Plasmatherm II is a safe and effective method for fresh frozen plasma (FFP). This method preserves clotting factors and prevents bacterial contamination, unlike traditional wet thawing methods.
Area of Science:
- Transfusion Medicine
- Hematology
- Clinical Pathology
Background:
- Fresh frozen plasma (FFP) requires thawing before transfusion.
- Improper thawing can denature plasma proteins and increase contamination risk.
Purpose of the Study:
- Compare wet versus dry thawing methods for FFP.
- Evaluate effects on clotting factors, bacterial contamination, and efficiency.
Main Methods:
- Thawed 42 FFPs using Plasmatherm II (dry) or a water bath (wet).
- Assessed coagulation parameters (PT, aPTT, fibrinogen, FVIII).
- Monitored bacterial contamination, throughput, and turnaround time.
Main Results:
- Both methods showed statistically significant changes in coagulation parameters post-thaw (P < 0.05), but remained within normal limits.
- No significant differences in coagulation parameters were observed between the two thawing methods (P > 0.05).
- Bacterial growth was detected in the water bath used for wet thawing.
Conclusions:
- Plasmatherm II offers a safe and efficient alternative to water bath thawing for FFP.
- Dry thawing preserves coagulation factors and mitigates bacterial contamination risks.
