Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method
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Published on: August 18, 2017
Shiho Sairenji1,2, Takashi Kikuchi1,2, Mohamed Ahmed Abozeid3
1Department of Applied Chemistry , School of Engineering , The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku , Tokyo 113-8656 , Japan .
Abstract:
Determination of the absolute configuration of chiral tetra-substituted carbon centers is one of the most taxing steps in the enantioselective construction of this structural motif in asymmetric synthesis. Here, we demonstrate that the crystalline sponge method provides an effective way to crystallographically determine the absolute configuration of organic compounds bearing chiral quaternary carbons (including tetra-substituted ones) that are synthesized by recently developed enantioselective catalytic reactions.
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