Related Experiment Video
Updated: Feb 21, 2026
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry
Daniel J Tward1,2, Chelsea S Sicat1, Timothy Brown1
1Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
Introduction:
Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease.
Methods:
Here, we study this region in subjects with mild cognitive impairment (n = 36) and in control subjects (n = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time.
Results:
We find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing.
Discussion:
This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.
