[The enzyme diagnosis of liver involvement in meningococcal infection]

A complex of blood enzymes (AST, ALT, AP, GTT) was studied in 84 patients with generalized forms of MI. The study showed that signs of liver involvement were noted in 15.4% of the patients on the 1st day of disease. Laboratory signs of cytolysis and cholestasis were revealed in most examinees on the 7th-15th day of disease during a dynamic follow-up. The most noticeable syndromes were revealed in young patients (30 persons) with brain edema (42.2%). Primary liver involvement (i. e. noted on admission to hospital) in 6 patients was associated with MI toxic effects, in 7 patients--with a severe concomitant pathology of the pulmonary and cardiovascular system. Delayed liver involvement was detected in 55.3% of the young patients and in half of the elderly patients. It was established that a course of disease was accompanied by the affection of many organs from the first days complicating the interpretation of enzymological data therefore requiring combined enzymological investigations.