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Related Experiment Video

Updated: Feb 21, 2026

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

Published on: January 3, 2025

Neutrophil programming dynamics and its disease relevance.

Taojing Ran^1,2, Shuo Geng¹, Liwu Li³

¹Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.

Science China. Life Sciences

|October 4, 2017

Summary

Neutrophils, once seen only as infection fighters, are now known to dynamically change their functions. Understanding these programmed neutrophils is key to understanding diseases.

Keywords:

immune priming inflammatory diseases neutrophils programming dynamics

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ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

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Isolation and Characterization of Neutrophils with Anti-Tumor Properties

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Published on: June 19, 2015

Area of Science:

Immunology
Cell Biology

Background:

Neutrophils traditionally act as the first responders to infection, crucial for antimicrobial defense.
Emerging evidence highlights neutrophils' dynamic functional states and their role in modulating host immune environments.
Diverse neutrophil subsets are increasingly recognized as key mediators in host pathophysiology.

Purpose of the Study:

To review the emerging concepts of neutrophil programming dynamics.
To discuss the functional relevance of these dynamic neutrophil states in various diseases.
To emphasize the need for integrative studies on neutrophil programming.

Main Methods:

This review synthesizes current research and literature.
It focuses on molecular mechanisms and functional relevance.
Integrative approaches are highlighted as essential.

Main Results:

Neutrophils exhibit dynamic programming, adopting distinct functional states beyond initial infection response.
These programmed neutrophils significantly influence host immune environments and disease pathophysiology.
The complexity of neutrophil functions necessitates a deeper understanding of their programming.

Conclusions:

Neutrophil programming dynamics are a critical area of study with significant implications for human health.
Further research into the molecular basis and disease relevance of programmed neutrophils is warranted.
Understanding these dynamic functions is essential for developing novel therapeutic strategies.