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Increased CD11b+ cells and Interleukin-1 (IL-1) alpha levels during cardiomyopathy induced by chronic adrenergic

Jeremy Ben-Shoshan1, Ayman Jubran1, Ran Levy1

  • 1Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

The Israel Medical Association Journal : IMAJ
|October 4, 2017
PubMed

Insights

Systemic CD11b+ cells and IL-1 signaling are linked to cardiomyopathy from chronic adrenergic stimulation. This suggests a role for immune system modulation in heart disease development.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Cell Biology

Background:

  • Systemic CD11b+ cells are implicated in various cardiac conditions, including chronic heart failure.
  • Understanding the role of immune cells in cardiac disease is crucial for developing new therapies.

Purpose of the Study:

  • To investigate the levels of circulating CD11b+ cells and pro-inflammatory cytokines in rats with cardiomyopathy induced by chronic adrenergic stimulation.
  • To explore the relationship between systemic immune markers and cardiac dysfunction.

Main Methods:

  • Male Lewis rats received low-dose isoproterenol for 3 months to induce cardiomyopathy.
  • Echocardiography assessed cardiac function, flow cytometry quantified CD11b+ cells, and cytokine arrays measured inflammatory markers.
  • Real-time PCR analyzed cardiac IL-1 receptor expression, and histology evaluated fibrosis and inflammation.

Main Results:

  • Isoproterenol induced cardiac hypertrophy, fibrosis, and dysfunction, with increased heart rate and heart weight-to-body weight ratio.
  • CD11b+ cells accumulated in the spleen, but cardiac inflammation was not observed.
  • Elevated serum IL-1 alpha and cardiac IL-1 receptor type 2 overexpression correlated with cardiac dysfunction.

Conclusions:

  • Systemic CD11b+ cell levels and IL-1 signaling pathways are associated with cardiomyopathy induced by chronic adrenergic stimulation.
  • These findings highlight the potential involvement of systemic immunomodulation in this type of cardiomyopathy.
  • Further research is warranted to elucidate the precise role of systemic immunity in cardiac disease.
Abstract

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