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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
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Steroidal Oximes: Useful Compounds with Antitumor Activities.
Catarina Canario1, Samuel Silvestre1,2, Amilcar Falcao2,3
1CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200- 506 Covilha, Portugal.
Current Medicinal Chemistry
|October 4, 2017
Summary
Steroidal oximes show promising anticancer activity by inhibiting key enzymes. Further research is needed to confirm their effectiveness and safety for clinical use.
Area of Science:
- Medicinal Chemistry
- Organic Chemistry
- Pharmacology
Background:
- Steroids are vital in biological processes and medicine, including anticancer therapies.
- Incorporating oxime groups into molecules can enhance their biological effects.
- Steroidal oximes are emerging as a significant class of compounds with anticancer potential.
Purpose of the Study:
- To review steroidal oximes with anticancer properties.
- To explore their mechanisms of action and relative potencies.
- To provide an overview of recent advances in the field.
Main Methods:
- Extensive literature search on PubMed, ISI Web of Knowledge, and Science Direct.
- Keywords included 'steroidal oximes,' 'anticancer activity,' and 'enzymatic inhibitory activity.'
- Evaluation of abstracts and full texts for scientific merit and relevance.
Main Results:
- Steroidal oximes exhibit significant antitumor activities and inhibit enzymes like steroid sulfatase, aromatase, and 5α-reductase.
- Pregnenolone 20-oximes are potent inhibitors of 17α-hydroxylase-17,20-lyase and 5α-reductase.
- Oxime group introduction at C-6 in androstane derivatives shows aromatase inhibition; functional group position impacts activity.
Conclusions:
- Advances in synthesis and in vitro studies highlight the potential of steroidal oximes as anticancer agents.
- Cytotoxic and enzyme inhibitory activity are dependent on the oxime group's position on the steroid scaffold.
- Further in vitro and in vivo studies are essential to validate their clinical effectiveness and safety.
Keywords:
Steroidal oximesanticancer activityantitumor activityenzymatic inhibitory activityrelative potencysteroid scaffold.More Related Videos
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