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Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis.

Ejaife O Agbani1, Alastair W Poole1

  • 1School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, United Kingdom.

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Summary

This review proposes "procoagulant platelet" as a unifying term for activated platelets that localize coagulation. These versatile platelets have biomarker potential for thrombotic events and can be targeted by new antithrombotic therapies.

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Area of Science:

  • Hematology
  • Biochemistry
  • Cell Biology

Background:

  • Platelets play a crucial role in localizing coagulation to wound sites.
  • Previous research has focused on a subpopulation of activated platelets with diverse descriptive titles.
  • Overlapping characteristics suggest a single, versatile platelet subpopulation.

Purpose of the Study:

  • To review four decades of data on activated platelets involved in coagulation.
  • To propose a unifying term for this platelet subpopulation.
  • To discuss the molecular mechanisms and clinical implications of these platelets.

Main Methods:

  • Comprehensive literature review of studies on activated platelets and coagulation over the past 40 years.
  • Analysis of reported characteristics to identify commonalities.
  • Discussion of agonist requirements and molecular drivers of platelet transformation.

Main Results:

  • Striking overlaps in reported platelet characteristics indicate a single, versatile subpopulation.
  • The term "procoagulant platelet" is proposed as unifying terminology.
  • Agonist requirements and molecular drivers for platelet transformation are discussed.

Conclusions:

  • Unifying the description of this platelet subpopulation under the term "procoagulant platelet" is necessary.
  • Procoagulant platelets hold potential as biomarkers for thrombotic events.
  • Inhibitors of carbonic anhydrase and Aquaporin-1 may offer novel antithrombotic strategies targeting procoagulant platelets.