Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The economic burden of dementia in Europe: COIN-Eu dementia.

Journal of Alzheimer's disease : JAD·2026
Same author

Movement disorders in GLUT1 deficiency syndrome: a systematic review of the literature.

Journal of neurology·2026
Same author

Decoding splicing variants in high-throughput sequencing: a functional validation approach integrating deep learning tools.

European journal of human genetics : EJHG·2026
Same author

One brain, one mind: A joint EPA-EAN leadership perspective on brain health.

European psychiatry : the journal of the Association of European Psychiatrists·2026
Same author

Palliative Care in Europe: Safeguarding Compassion Amidst Changing End-of-Life Policies and Expanding Access to Medically Assisted Dying Position Statement on behalf of the European Academy of Neurology, the European Federation of Neurological Associations and OneNeurology.

European journal of neurology·2026
Same author

Untangling neurophysiology of Tourette syndrome using dual-target bi-pallidal deep brain stimulation.

Parkinsonism & related disorders·2026

Related Experiment Video

Updated: Feb 21, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.2K

Pallidal deep brain stimulation for dystonia: a long term study.

Sara Meoni1,2, Valérie Fraix1, Anna Castrioto1

  • 1Division of Neurology, CHU of Grenoble, Grenoble Alpes University, Grenoble, France.

Journal of Neurology, Neurosurgery, and Psychiatry
|October 4, 2017
PubMed
Summary

Globus pallidus internus deep brain stimulation (GPi DBS) significantly improved motor and disability scores in patients with isolated idiopathic and inherited dystonia, as well as acquired dystonia. Long-term follow-up confirmed GPi DBS as an effective and safe treatment option.

Keywords:
deep brain stimulationdystoniaglobus pallidusmotor outcome

More Related Videos

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

20.6K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.4K

Related Experiment Videos

Last Updated: Feb 21, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.2K
Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

20.6K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.4K

Area of Science:

  • Neurology
  • Neurosurgery
  • Movement Disorders

Background:

  • Globus pallidus internus deep brain stimulation (GPi DBS) is a primary treatment for disabling isolated idiopathic (IID) and inherited (INH) dystonia.
  • Acquired dystonia (AD) may also benefit from GPi DBS, but long-term efficacy and safety require further evaluation.

Purpose of the Study:

  • To retrospectively assess the long-term clinical outcomes and safety of GPi DBS in patients with dystonia.

Main Methods:

  • Sixty-one patients with dystonia underwent GPi DBS.
  • Clinical outcomes were assessed preoperatively and postoperatively using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor and disability scores.
  • Long-term follow-up averaged 7.9 years.

Main Results:

  • Significant improvements in BFMDRS motor scores were observed in IID/INH and AD patients at long-term follow-up.
  • BFMDRS disability scores also improved significantly in IID/INH and AD patients.
  • Adverse events were predominantly hardware-related.

Conclusions:

  • GPi DBS demonstrates long-term efficacy in improving motor function and disability in most patients with dystonia.
  • The procedure is considered safe for the long-term management of dystonia.
  • Further research may explore outcomes in specific subtypes like INH dystonia with other neurological features.