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Viral oncoproteins and ubiquitination: accessing a cellular toolbox for modifying protein function

Miranda Thomas1, Lawrence Banks1

  • 1ICGEB, Trieste, Italy.

The FEBS Journal
|October 4, 2017
PubMed

Insights

Human Papillomavirus oncoproteins disrupt the Ubiquitin Proteasome System (UPS). This manipulation aids viral replication and contributes to cancer development by affecting apoptosis, transcription, and immunity.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Human Papillomavirus (HPV) is a common viral infection.
  • The Ubiquitin Proteasome System (UPS) regulates protein degradation and cellular processes.
  • Dysregulation of the UPS is implicated in various cancers.

Purpose of the Study:

  • To investigate how HPV oncoproteins interact with the UPS.
  • To understand the consequences of UPS perturbation by HPV.
  • To explore the link between UPS manipulation and cancer development.

Main Methods:

  • The study focuses on the molecular interactions between HPV oncoproteins and UPS components.
  • Cellular processes affected by this interaction were analyzed.

Main Results:

  • HPV oncoproteins directly target and interfere with the UPS.
  • This interference perturbs cellular processes including apoptosis, transcription, and innate immunity.
  • The altered cellular environment favors viral replication.

Conclusions:

  • HPV's manipulation of the UPS is a key mechanism for viral replication.
  • This disruption of cellular processes contributes to the development of HPV-associated malignancies.
  • Targeting the UPS presents a potential strategy for cancer therapy.

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