INSULIN LIKE GROWTH FACTOR 1 POSSIBLE DEPENDENCE IN PATIENTS WITH METABOLIC SYNDROME OF NODULAR PATHOLOGY OF THE...

Area of Science:

• Endocrinology
• Metabolic Disorders
• Thyroid Pathology

Background:

• Metabolic syndrome and thyroid nodular disease are prevalent conditions.
• A potential link between these conditions has been observed.
• The insulin-like growth factor system (IGF), specifically IGF-1, is hypothesized as a connecting factor due to its role in cell growth.

Purpose of the Study:

• To investigate the relationship between metabolic syndrome, thyroid nodular disease, and insulin-like growth factor 1 (IGF-1) levels.
• To determine if IGF-1 acts as a mediator between metabolic syndrome and thyroid nodules.

Main Methods:

• Cross-sectional study involving 71 patients aged 18-82.
• Patients were divided into three groups: thyroid nodules with metabolic syndrome, thyroid nodules without metabolic syndrome, and metabolic syndrome without thyroid pathology.
• Assessed thyroid structure, carbohydrate metabolism, thyroid function, and serum IGF-1 concentrations.

Main Results:

• No increase in IGF-1 was observed in patients with thyroid nodular disease.
• IGF-1 levels were normal or reduced in patients with hyperinsulinemia.
• No statistically significant connection was found between IGF-1 and thyroid nodules across the studied groups.

Conclusions:

• The study did not reveal a significant association between IGF-1 and the presence of thyroid nodules.
• The hypothesis that IGF-1 is a connecting link between metabolic syndrome and thyroid nodular disease was not supported by these findings.
• Future studies will analyze IGF-1 in thyroid histological samples to further investigate this relationship.