Sipple's syndrome associated with a large prolactinoma
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Updated: Jul 12, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 18, 2010
J H Bertrand1, P Ritz, Y Reznik
1Department of Cardiology, Centre Hospitalo-Universitaire de Caen, France.
Abstract:
A 26-year-old male presented with the symptoms and signs of acute congestive heart failure and hypertension. The left ventricle was shown to be thickened and displayed reversible hypokinesia. Further investigations revealed the underlying pathology of a phaeochromocytoma, bilateral medullary thyroid carcinoma (MTC), parathyroid adenoma and macro-prolactinoma. There was a family history of MTC. The echocardiographic features of catecholamine-induced cardiomyopathy were important in this diagnosis. Our research revealed no previous report of Sipple's syndrome associated with a macroprolactinoma. This case, along with the other 13 reports of mixed (type I and II) multiple endocrine neoplasia (MEN), are not within the classical subsets of MEN.
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