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Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

The Molecular Design Research Network.

Philip Coish¹, Bryan W Brooks^2,3, Evan P Gallagher⁴

¹School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06520.

Toxicological Sciences : an Official Journal of the Society of Toxicology

|October 4, 2017

Summary

This summary is machine-generated.

The Molecular Design Research Network (MoDRN) fosters collaboration between chemists and toxicologists to design safer chemicals. This network applies Green Chemistry principles to minimize toxicity while preserving chemical product efficacy.

Keywords:

computational methods green chemistry guidelines in silico models molecular design molecular properties nexus safer chemical design systems thinking toxicology

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Area of Science:

Chemical safety
Toxicology
Green Chemistry

Background:

The need for safer commercial chemicals is critical.
Interdisciplinary collaboration is essential for advancing chemical design.
Existing chemical design often overlooks toxicity.

Purpose of the Study:

To provide an overview of the Molecular Design Research Network (MoDRN).
To highlight the network's goal of fostering collaboration between chemists and toxicologists.
To promote the rational design of safer commercial chemicals.

Main Methods:

Establishment of the Molecular Design Research Network (MoDRN) in 2013.
Funding through the EPA-National Science Foundation Networks for Sustainable Molecular Design and Synthesis (NSMDS) program.
Leadership by four major universities: Baylor, University of Washington, The George Washington University, and Yale.

Main Results:

Fostered interdisciplinary collaboration between chemists and toxicologists.
Enabled the application of Green Chemistry principles to chemical design.
Initiated the rational design of safer commercial chemicals.

Conclusions:

The MoDRN network effectively promotes the design of safer chemicals.
Interdisciplinary approaches are key to minimizing chemical toxicity.
The network's work aligns with the fourth Principle of Green Chemistry.