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Related Experiment Videos

Bone cement and the liver. A dose-related effect?

I K Pople1, H Phillips

  • 1Department of Orthopaedics, Norfolk and Norwich Hospital, England.

The Journal of Bone and Joint Surgery. British Volume
|May 1, 1988
PubMed
Summary

Bone cement used in hip replacements temporarily elevates serum liver enzymes, particularly gammaglutamyl transferase. This effect is dose-related to the amount of cement used and resolves over time.

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Area of Science:

  • Orthopedic Surgery
  • Hepatology
  • Biomaterials Science

Background:

  • Hip replacement surgery is a common orthopedic procedure.
  • Bone cement is frequently used to fix implants during hip arthroplasty.
  • Potential systemic effects of bone cement components require investigation.

Purpose of the Study:

  • To evaluate the impact of bone cement on liver function post-hip replacement.
  • To compare liver enzyme changes in patients receiving cemented versus uncemented hip arthroplasty.
  • To determine if there is a correlation between cement volume and liver enzyme elevation.

Main Methods:

  • Prospective study comparing 40 patients undergoing cemented hip replacement with 36 controls receiving uncemented procedures.
  • Measurement of serum liver enzymes, specifically SGGT, before and after surgery.
  • Statistical analysis to correlate SGGT changes with the weight of bone cement used.

Main Results:

  • 32% of patients (12/40) receiving bone cement showed elevated SGGT levels for over four days post-operation.
  • Only one control patient (1/36) exhibited SGGT elevation.
  • A significant positive correlation was found between the weight of cement used and SGGT level changes (r=0.66, p<0.001).

Conclusions:

  • Bone cement exerts a temporary, dose-dependent effect on liver function, indicated by transient SGGT elevation.
  • The observed liver enzyme changes normalize in all patients.
  • This suggests careful consideration of cement volume in patients with pre-existing liver conditions.

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