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Blueberry and malvidin inhibit cell cycle progression and induce mitochondrial-mediated apoptosis by abrogating the

Abdul Basit Baba1, Ramesh Nivetha1, Indranil Chattopadhyay2

  • 1Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|October 5, 2017
PubMed

Insights

Blueberries and malvidin inhibit the STAT-3 pathway, a key factor in oral cancer development. Combining them with other inhibitors enhances their anticancer effects, offering new therapeutic strategies.

Area of Science:

  • Biochemistry
  • Oncology
  • Nutraceuticals

Background:

  • Blueberries are rich in anthocyanins and recognized for health benefits, including anticancer properties.
  • STAT-3 is an oncogenic transcription factor implicated in various cancers, making it a therapeutic target.

Purpose of the Study:

  • To investigate the potential of blueberries and malvidin in targeting the JAK/STAT-3 pathway in oral cancer.
  • To elucidate the mechanisms by which blueberry and malvidin exert anticancer effects.

Main Methods:

  • Assessment of blueberry and malvidin effects on the JAK/STAT-3 pathway in a hamster model of oral oncogenesis.
  • Mechanistic studies in the oral cancer cell line SCC131, including analysis of STAT-3 phosphorylation and nuclear translocation.
  • Evaluation of combination therapy with blueberry, malvidin, and the STAT-3 inhibitor S3I-201.

Main Results:

  • Blueberry abrogates the JAK/STAT-3 pathway and modulates downstream targets in oral oncogenesis.
  • Blueberry and malvidin inhibit STAT-3 phosphorylation and nuclear translocation in oral cancer cells.
  • Combination therapy with blueberry, malvidin, and S3I-201 showed enhanced STAT-3 inhibition.

Conclusions:

  • Blueberry and its constituent malvidin act as STAT-3 inhibitors, inducing cell cycle arrest and apoptosis.
  • Combination of blueberry and malvidin with STAT-3 inhibitors presents a promising strategy for oral cancer therapy.
  • This study provides a basis for developing novel STAT-3 signaling inhibitors for cancer treatment.
Keywords:
ApoptosisBlueberryCell cycleHamster buccal pouch carcinogenesisMalvidinSTAT-3

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