Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

48.8K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
48.8K
Genomics02:02

Genomics

40.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.8K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

3.5K
No description available
3.5K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

16.8K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
16.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiating Etiologies of Pain in the Presence of Dorsal Arachnoid Web: A Case Report.

Pain medicine case reports·2026
Same author

The AAHKS Clinical Research Award: Maximizing Bearing Size Markedly Reduces Dislocations in Primary Total Hip Arthroplasty.

The Journal of arthroplasty·2026
Same author

Endoscopic resection of knosp grade 0-2 growth hormone-secreting pituitary adenomas with routine medial cavernous sinus wall excision.

Acta neurochirurgica·2026
Same author

Design, Preclinical Evaluation, and Clinical Translation of [68Ga]Ga/[177Lu]Lu-JH120061, A Novel Radiopharmaceutical Targeting CXCR4.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Estimating temporal treatment-effect patterns of radiotherapy and chemotherapy in lower-grade gliomas using causal machine learning.

Scientific reports·2026
Same author

Differential epigenetic regulation of glucose-induced alteration of miR-9 in retinal and cardiac endothelial cells.

PloS one·2026

Related Experiment Video

Updated: Feb 9, 2026

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Targeting the Noncoding Genome: Superenhancers Meet Their Kryptonite.

Eric Wang1, Ioannis Aifantis1

  • 1Department of Pathology and Perlmutter Cancer Center, NYU School of Medicine, New York, New York. Ioannis.Aifantis@nyumc.org eric.wang@nyumc.org.

Cancer Discovery
|October 5, 2017
PubMed
Summary

Researchers identified a new RARA superenhancer in acute myeloid leukemia (AML) subtypes. This finding makes leukemia cells sensitive to SY-1425, a drug that promotes myeloid differentiation in RARA-high AML.

More Related Videos

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K
Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.0K

Related Experiment Videos

Last Updated: Feb 9, 2026

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K
Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.0K

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Acute myeloid leukemia (AML) is a heterogeneous blood cancer.
  • Understanding the regulatory elements like enhancers is crucial for targeted therapies.
  • The role of RARA (retinoic acid receptor alpha) in AML pathogenesis is complex.

Purpose of the Study:

  • To perform a genome-wide characterization of the enhancer landscape in AML.
  • To identify novel regulatory elements driving AML.
  • To explore therapeutic strategies targeting specific AML subtypes.

Main Methods:

  • Genome-wide enhancer profiling.
  • Analysis of superenhancer regions in AML patient samples.
  • Functional studies using RARA agonists.

Main Results:

  • Discovery of a novel RARA superenhancer in a subset of AML patients.
  • Identification of high RARA expression in these AML subtypes.
  • Demonstration of high sensitivity of these leukemia cells to SY-1425, a RARA agonist.

Conclusions:

  • A specific RARA superenhancer is associated with a subset of AML.
  • Targeting this superenhancer with RARA agonists like SY-1425 can induce myeloid differentiation.
  • This provides a potential targeted therapeutic strategy for RARA-high AML.