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The Association Between Lung Carcinoma and Tuberculosis
1Clinic for Pulmonary Disease and TB "Podhrastovi", University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Medical Archives (Sarajevo, Bosnia and Herzegovina)
|October 5, 2017
Summary
Patients with a history of treated tuberculosis have an increased risk of developing lung cancer. Continuous monitoring of these patients is crucial for early detection of lung carcinoma.
Area of Science:
- Pulmonology
- Oncology
- Infectious Diseases
Background:
- The link between lung tuberculosis (TB) and lung carcinoma (LC) remains a subject of debate.
- Understanding this association is vital for patient management and risk stratification.
Purpose of the Study:
- To characterize patients with co-occurring lung tuberculosis and lung carcinoma.
- To analyze the clinical and pathological features of this patient cohort.
Main Methods:
- Retrospective analysis of patients diagnosed with both TB and LC between 2012 and 2016.
- Data collected included patient demographics, disease progression (TB preceding LC or vice versa), time intervals, TB activity, and LC histopathology and location.
Main Results:
- Out of 2608 LC patients, 34 (1.3%) also had TB; all were smokers.
- TB consistently preceded LC, with a median time of 5 years.
- No active TB was observed; all patients had prior TB treatment.
- LC types included drainage bronchus carcinoma (21 cases), peripheral lung carcinoma (11 cases), and cavern carcinoma (2 cases).
Conclusions:
- Individuals with a history of treated pulmonary tuberculosis are at higher risk for developing lung carcinoma.
- Tuberculosis-induced mucosal changes may predispose to malignant transformation.
- Ongoing surveillance of patients with any form of pulmonary tuberculosis is recommended.
Keywords:
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