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Updated: Feb 21, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Laryngopharyngeal Reflux Disease - LPRD
Nizama Salihefendic1, Muharem Zildzic2, Emir Cabric3
1Department of Emergency Medicine, Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina.
Laryngopharyngeal reflux disease (LPRD) affects nearly 20% of patients visiting family medicine. Primary care can effectively diagnose and treat LPRD, with 82% improving with basic interventions.
Area of Science:
- Family Medicine
- Gastroenterology
- Otolaryngology
Background:
- Laryngopharyngeal reflux disease (LPRD) involves stomach content reflux into the esophagus, causing inflammation in the throat and larynx.
- LPRD presents with diverse symptoms and is often diagnosed late, highlighting the need for a unified approach in primary care.
- It is frequently misdiagnosed or considered a manifestation of gastroesophageal reflux disease (GERD).
Purpose of the Study:
- To determine the prevalence of LPR symptoms in family medicine settings.
- To evaluate diagnostic methods and appropriate primary care treatment strategies for LPRD.
- To assess the effectiveness of a proposed diagnostic and treatment algorithm in primary healthcare.
Main Methods:
- A prospective, descriptive cohort study was conducted over one year.
- The Reflux Symptom Index (RSI) questionnaire was used for initial screening.
- Patients with positive LPR results (RSI > 13) received treatment per a suggested algorithm and were monitored.
Main Results:
- Out of 2123 patients screened, 390 (18.4%) tested positive for LPR symptoms.
- The treated group showed an 82% improvement rate in response to the basic treatment protocol.
- A significant majority of patients responded positively to interventions managed within primary care.
Conclusions:
- Nearly one in five patients presenting to family medicine exhibit LPR symptoms.
- Primary healthcare settings can effectively implement prevention, diagnosis, and treatment for LPRD using established algorithms.
- Most LPRD cases can be managed in primary care, with only a small fraction requiring referral to specialized fields.
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