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Recent Updates on Acquired Hepatocerebral Degeneration

Hae-Won Shin1,2, Hee Kyung Park3,4

  • 1Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|October 5, 2017
PubMed

Insights

Acquired hepatocerebral degeneration (AHD) involves toxic substance accumulation and neuroinflammation, causing neurological issues in liver disease patients. Neuroimaging reveals specific brain changes, aiding diagnosis of this complex syndrome.

Area of Science:

  • Neurology
  • Hepatology
  • Radiology

Background:

  • Acquired hepatocerebral degeneration (AHD) is a chronic neurological condition linked to advanced liver disease.
  • It presents with diverse neurological symptoms and characteristic neuroimaging findings.

Purpose of the Study:

  • To review the pathomechanism and neuroimaging findings in acquired hepatocerebral degeneration (AHD).
  • To consolidate current understanding of this complex neurological syndrome.

Main Methods:

  • A comprehensive literature search was conducted using PubMed.
  • Keywords included "acquired hepatocerebral degeneration," "cirrhosis-related parkinsonism," and "manganese and liver disease."

Main Results:

  • AHD pathogenesis involves toxic accumulation (ammonia, manganese) and neuroinflammation.
  • Clinical features include parkinsonism, ataxia-plus syndrome, cognitive, and psychiatric impairments.
  • Neuroimaging shows globus pallidus T1 hyperintensity in parkinsonism and cerebellar peduncle T2 lesions in ataxia-plus syndrome.

Conclusions:

  • Further research is required to fully understand the heterogeneous mechanisms and neuroimaging characteristics of AHD.
  • Elucidating these aspects will improve diagnosis and management of AHD.
Abstract

Keywords:
Acquired hepatocerebral degenerationdopamine transporter imagingliver cirrhosismanganeseneuroinflammationparkinsonism

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