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Updated: Feb 21, 2026

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Reporting renal biopsies from Cyprus: a systematic approach.

Düriye Deren Oygar1, Guy H Neild2

  • 1Department of Nephrology, Nicosia State Hospital, Burhan Nalbantoglu General Hospital, North Cyprus.

Journal of Nephropathology
|October 5, 2017
PubMed
Summary

Renal disease causes vary globally. In North Cyprus, primary glomerulonephritis (GN) is common, with secondary focal and segmental glomerulosclerosis (FSGS) frequently observed, potentially linked to monogenic disorders.

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Area of Science:

  • Nephrology
  • Renal Pathology
  • Epidemiology

Background:

  • Renal disease etiology differs worldwide, with unknown or hypertension-related causes prevalent in the Middle East.
  • This study focuses on the renal biopsy findings in North Cyprus.

Purpose of the Study:

  • To establish a reproducible renal biopsy series for comparative analysis across different centers.
  • To characterize the spectrum of kidney diseases in North Cyprus.

Main Methods:

  • A 10-year retrospective analysis of native kidney biopsies from 153 adult patients in North Cyprus.
  • Data collection included patient demographics and histopathological findings.

Main Results:

  • The most common diagnoses were primary glomerulonephritis (GN) (56%) and secondary GN (27%).
Keywords:
Chronic kidney diseaseMiddle EastPrimary renal diseaseRenal biopsyRenal failure

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  • Secondary focal and segmental glomerulosclerosis (FSGS) was a significant finding (29% of primary GN cases).
  • The incidence of IgA nephropathy was 6.3 per million population per year.

    • Conclusions:

    • Standardized reporting of renal biopsy data, including population incidence (per million population/year) and biopsy rates, is crucial for inter-center comparison.
    • Secondary FSGS is notably common in this population and may stem from monogenic causes.
    • Further investigation into the genetic basis of FSGS in this region is warranted.