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Spiral microchannel with ordered micro-obstacles for continuous and highly-efficient particle separation.

Shaofei Shen1, Chang Tian, Tianbao Li

  • 1College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China. liuwenming0229@nwsuaf.edu.cn jywang@nwsuaf.edu.cn.

Lab on a Chip
|October 5, 2017
PubMed
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This study presents a novel inertial microfluidic system for efficient particle separation. Micro-obstacles in spiral channels enhance particle focusing, enabling high-throughput separation of various particles like circulating tumor cells.

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Microfluidics

Background:

  • Controllable fluid flow is essential for particle separation in biomedical and industrial applications.
  • Inertial microfluidics utilizes inertial forces and Dean effect for particle positioning.
  • Existing methods require further optimization for efficiency and throughput.

Purpose of the Study:

  • To develop a novel inertial microfluidic system for highly efficient particle separation.
  • To investigate the regulation of Dean-like secondary flow using geometric confinement and micro-obstacles.
  • To demonstrate high-throughput, sheathless separation of various particles.

Main Methods:

  • Design and fabrication of a spiral microchannel system.
  • Introduction of micro-obstacles to manipulate secondary flow.

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  • Utilizing linear acceleration of secondary flow for particle focusing.
  • Demonstration of particle separation using polymeric particles, circulating tumor cells, and blood cells.

    • Main Results:

    • Demonstrated regulation of Dean-like secondary flow via geometric confinement.
    • Micro-obstacles significantly enhanced particle focusing in time and space.
    • Achieved sheathless, high-throughput (3 ml/min) particle separation with up to 99.8% focusing efficiency.
    • Successful long-term (≥4 h) particle separation and sorting.

    Conclusions:

    • The developed inertial microfluidic system offers an effective and high-throughput method for particle manipulation.
    • Geometric confinement and micro-obstacles are key to enhancing secondary flow for particle focusing.
    • This technology has potential for laboratory and commercial applications in life and material sciences.