Related Experiment Video

Updated: Feb 21, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.7K

Etiology of community-acquired pneumonia in 1500 hospitalized children

Hao Oumei1, Wang Xuefeng1, Liu Jianping2

  • 1Affiliated Hospital to Liaoning University Traditional Chinese Medicine, Shenyang, China.

Journal of Medical Virology
|October 5, 2017
PubMed

Insights

Mycoplasma pneumoniae and respiratory viruses are common causes of childhood community-acquired pneumonia (CAP) in China. Identifying these pathogens could prevent over half of CAP hospitalizations through vaccination.

Area of Science:

  • Pediatric Infectious Diseases
  • Respiratory Medicine
  • Microbiology

Background:

  • Childhood community-acquired pneumonia (CAP) is a significant global health concern.
  • Limited prospective, multicenter data exists on CAP etiology in hospitalized Chinese children.
  • Understanding causative pathogens is crucial for effective prevention and treatment strategies.

Purpose of the Study:

  • To identify the primary respiratory pathogens responsible for CAP in hospitalized children across China.
  • To determine the prevalence of specific viral and bacterial agents, including Mycoplasma pneumoniae.
  • To assess the rate of co-infections in pediatric CAP cases.

Main Methods:

  • Prospective, multicenter study conducted from January to December 2015.
  • Oropharyngeal swabs and blood serum collected from 1500 children (6 months–14 years) with CAP.
  • Immunofluorescence and passive agglutination assays used to detect eight respiratory viruses and Mycoplasma pneumoniae.

Main Results:

  • 691 out of 1500 (46.1%) children tested positive for at least one pathogen.
  • Mycoplasma pneumoniae was the most frequent pathogen (32.4%), followed by respiratory syncytial virus (11.5%) and adenovirus (5.0%).
  • Co-infections were present in 18.5% of positive cases.

Conclusions:

  • Mycoplasma pneumoniae and common respiratory viruses are key contributors to pediatric CAP in China.
  • Vaccination against RSV, adenovirus, and M. pneumoniae could potentially prevent over half of these CAP hospitalizations.
  • Further etiological investigations are needed to optimize pneumonia management in children.

Keywords:
Mycoplasma pneumoniaechildrencommunity-acquired pneumoniamulticenter researchrespiratory viruses

More Related Videos

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling08:25

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

9.5K
A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

3.2K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
971
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
950
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
3.3K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
3.7K
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
852
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
815