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Updated: Feb 21, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
Published on: December 1, 2017
Yield prediction in parallel homogeneous assembly
Dhananjay Ipparthi1, Andrew Winslow, Metin Sitti
1IRIDIA, CoDE, Université libre de Bruxelles, Brussels, Belgium. dhananjay.ipparthi@ulb.ac.be.
Abstract:
We investigate the parallel assembly of two-dimensional, geometrically-closed modular target structures out of homogeneous sets of macroscopic components of varying anisotropy. The yield predicted by a chemical reaction network (CRN)-based model is quantitatively shown to reproduce experimental results over a large set of conditions. Scaling laws for parallel assembling systems are then derived from the model. By extending the validity of the CRN-based modelling, this work prompts analysis and solutions to the incompatible substructure problem.
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