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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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[Metabolic programming: theoretical concepts and experimental evidence]
O G Zabuga1, N G Akhaladze1, A M Vaiserman1
1D. F. Chebotarev State Institute of Gerontology, NAMS of Ukraine, Kiev 04114, Ukraine; vaiserman@geront.kiev.ua.
Advances in Gerontology = Uspekhi Gerontologii
|October 5, 2017
Summary
Poor nutrition during fetal development, known as nutritional programming, can increase chronic disease risk later in life. This programming involves epigenetic gene regulation, impacting lifespan and age-related pathologies.
Area of Science:
- Developmental biology
- Epigenetics
- Nutritional science
Context:
- Poor nutrition during fetal development is linked to chronic diseases later in life.
- This phenomenon is termed 'nutritional programming of age-related pathologies'.
- Early life dietary deficiencies may trigger adaptations for survival, impacting later health.
Purpose:
- To review experimental evidence on the role of early development nutrition in adult health.
- To highlight the influence of dietary restrictions on age-related disease risk and lifespan.
- To explore the epigenetic mechanisms underlying nutritional programming.
Summary:
- Qualitative or quantitative nutritional deficiencies during early development can lead to adaptive changes.
- These adaptations, while beneficial for early survival, may increase the risk of pathologies in later life.
- Epigenetic regulation of gene activity is a key mechanism mediating these long-term effects.
Impact:
- Understanding nutritional programming is crucial for preventing adult-onset chronic diseases.
- Early life nutrition interventions can mitigate risks associated with developmental dietary exposures.
- This research informs public health strategies and personalized nutrition approaches for lifelong health.
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